"VEGF and Cancer" is a comprehensive and up to date review of current knowledge on the role of vascular endothelial growth factor (VEGF) in cancer. Key features include: discussion of VEGF as potent angiogenic factor and its role in tumor angiogenesis; review of the biology, molecular properties and regulation of VEGF; discussion of the role of VEGF in a range of different tumor types, both solid tumors and haematological cancers; review of the therapeutic potential of different approaches to block VEGF; review of recent evidence that in addition to its role as an endothelial cell mitogen; VEGF may also be an autocrine growth factor for tumor cells; and regulating survival and invasion. This book is aimed at scientists new to angiogenesis and VEGF biology and provides new information for established researchers and scientists. It will also be a useful text for clinicians interested in anti-angiogenic therapy for treatment of human cancers.
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