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The Oncogenomics Handbook 在线电子书 pdf 下载 txt下载 epub 下载 mobi 下载 2024

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LaRochelle, William J., Ph.D. (EDT)/ Shimkets, Richard A. (EDT) 作者

Humana Pr Inc

译者

2005-4 出版日期

768 页数

$ 270.07 价格

HRD

丛书系列

9781588294258 图书编码

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The Oncogenomics Handbook 在线电子书 epub 下载 mobi 下载 pdf 下载 txt 下载 2024

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This is an integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.

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