The increasing incidence of esophageal adenocarcinoma has created an enormous interest and stimulus for research in this area. "GERD" brings together, for the first time, a vast amount of disparate literature and documents the entire pathogenesis of reflux disease in one place. The book presents reflux carditis as a new diagnostic criterion of GERD and for the first time defines the dilated end-stage esophagus and the earliest microscopic phase of GERD that is missed by present diagnostic criteria. "GERD" presents both clinical and pathological information and is meant to be used as a comprehensive reference for gastroenterologists, esophageal surgeons, and pathologists alike. It outlines how gastroesophageal reflux causes cellular changes in the esophagus. It brings together the pathogenesis of the disease in one source and applies it toward clinical treatment. Tom DeMeester is the leading international expert on reflux disease; and Parakrama Chandrasoma is one of the leading pathologists in the area. This book contains approximately 350 illustrations, and an ancillary web site features color illustrations.