Targeted Therapies in Cancer 在线电子书 pdf 下载 txt下载 epub 下载 mobi 下载 2024

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Dietel, Manfred (EDT) 作者

Springer Verlag

译者

出版日期

276 页数

$ 213.57 价格

HRD

丛书系列

9783540460909 图书编码

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发表于2024-11-24

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Targeted Therapies in Cancer 在线电子书 epub 下载 mobi 下载 pdf 下载 txt 下载 2024

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Targeted Therapies in Cancer 在线电子书图书描述

From its introduction, oncological chemotherapy has been encumbered by its poor selectivity because most antiproliferative drugs are toxic not only to tumor cells but also to important populations of the bodya (TM)s non-neoplastic cells. The resultant problems with unwanted side effects are compounded by difficulties in predicting the desired effectivity of chemotherapy in individual patients. This unsatisfactory situation has driven intensive research and development towards more specific and less toxic anticancer drugs over the last few decades. Several results of these efforts have reached the clinic and an even greater number are now in preclinical testing. Common to all these targeted therapies is their interaction with defined molecules present on cancer cells, which adds various degrees of increased selectivity to their toxic effects. As a consequence, detecting the target molecule on tumors before therapy holds great diagnostic potential for predicting the efficacy of the drug and personalizing therapy. This book aims to present translational scientists and clinicians with an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.

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