Nucleic Acid Switches and Sensors 在线电子书 pdf 下载 txt下载 epub 下载 mobi 下载 2024

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Silverman, Scott 编作者

Springer Verlag

译者

2006-8 出版日期

134 页数

$ 190.97 价格

HRD

丛书系列

9780387374918 图书编码

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Nucleic Acid Switches and Sensors 在线电子书 epub 下载 mobi 下载 pdf 下载 txt 下载 2024

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In this book, seven chapters describe studies aimed at understanding and exploiting the key features of such molecular RNA and DNA devices. In the first section of the book, four chapters are devoted to artificial nucleic acid switches and sensors. These chapters introduce the concept of allosteric ribozymes as molecular switches and sensors; describe nucleic acid enzymes that are switched by oligonucleotides and other nucleic acid enzymes that are switched by proteins; and illustrate how switching elements can be integrated ration-ally into fluorescently signaling molecular sensors made out of nucleic acids. In the second section of the book, three chapters show that nature has been as crafty a molecular-scale engineer as any modern scientist via evolution of natural nucleic acid switches and sensors. RNAs have been found whose activities are modulated either by proteins or by small-molecule metabolites, and both kinds of system are described. Finally, the notion of exploiting naturally occurring RNA switches for drug development is discussed.

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