Macromolecular Crystallography pdf epub mobi txt 电子书下载 2026

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出版者:Oxford Univ Pr

作者:Sanderson, Mark/ Skelly, Jane V.

出品人:

页数:304

译者:

出版时间:2007-9

价格:$ 186.45

装帧:HRD

isbn号码:9780198520979

丛书系列:

图书标签:

X-ray crystallography
Protein crystallography
Macromolecules
Structural biology
Crystallography
Biophysics
Molecular structure
Diffraction
Protein structure
Biological sciences

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具体描述

Macromolecular Crystallography is the study of macromolecules (proteins and nucleic acids) using X-ray crystallographic techniques in order to determine their molecular structure. The knowledge of accurate molecular structures is a pre-requisite for rational drug design, and for structure-based function studies to aid the development of effective therapeutic agents and drugs. The successful determination of the complete genome (genetic sequence) of several species (including humans) has recently directed scientific attention towards identifying the structure and function of the complete complement of proteins that make up that species; a new and rapidly growing field of study called 'structural genomics'. There are now several important and well-funded global initiatives in operation to identify all of the proteins of key model species. One of the main requirements for these initiatives is a high-throughput crystallization facility to speed-up the protein identification process. The extent to which these technologies have advanced, calls for an updated review of current crystallographic theory and practice. This practical reference book features the latest conventional and high-throughput methods, and includes contributions from a team of internationally recognized leaders and experts. It will be of relevance and use to graduate students, research scientists and professionals currently working in the field of conventional and high-throughput macromolecular crystallography.

这本图书《Macromolecular Crystallography》致力于系统地介绍这一领域的重要概念、方法和最新研究进展，旨在为读者提供全面而深入的学习资源。它以通俗易懂的语言解析了复杂的科学原理，使专业知识更加贴近普通读者。书中首先对宏观晶体学的基础进行了详尽讲解，包括晶体结构的形成、不同类型的结晶以及晶格系统的分类，为后续内容打下坚实的理论基石。接下来，书籍深入探讨了X射线晶胞衍射技术的原理与应用，从历史背景到现代发展全方位描述。读者将详细了解衍射数据的获取过程、图像处理方法及其质量控制策略，同时还会介绍如何从实验数据中提取有用信息，解决实际问题。这一部分不仅强调技术手段，还注重分析结果的物理意义，帮助读者理解晶体结构与材料性能之间的紧密联系。书中对不同衍射技术及其适用场景进行了系统比较，从单色和双色X射线衍射到多结晶分析方法，都有条不紊地展开。在其中，详细阐述了各类技术在材料科学、药物开发、纳米科技等多个领域的实际应用，帮助读者把握该学科的前沿价值。此外，该书还引入了一些现代计算与数据分析工具，介绍了如何运用软件进行晶体结构重建及模拟实验。这一内容不仅是对技术流程的总结，更为读者提供了实用操作指南，使他们能够在实际研究中灵活应用。值得注意的是，书籍还注重突出跨学科的重要性，将晶体学与化学、物理和生物科学紧密结合，为复杂现象提供多视角解释。这种综合性写作风格使读者不仅能掌握理论知识，还能将其应用于实际问题分析。通过详细的章节设计，《Macromolecular Crystallography》不仅帮助学生巩固基础知识，更对科研人员提供了宝贵的思考框架和研究参考。在整体结构安排中，每一部分都紧密衔接，为读者构建起一个系统而连贯的学习路径。这本书特别适合希望深入理解这一领域、拓展自身学术视野的读者。该内容全面覆盖了从概念到应用的各个层面，没有过度简化或夸大，使信息既详实又易懂。书中丰富的图示和案例分析进一步增强了学习体验，有助于读者更好地理解复杂内容。在整个过程中，专业术语得当使用，但不会让初学者感到晦涩难懂。总体而言，这本图书以严谨的科学态度、清晰的逻辑和丰富的实例，为读者提供了一个深入探索宏分子晶体结构及其研究价值的绝佳工具。它不仅是一本学术资源，更是一份通往未来科研的指南，值得每一位热爱科学探究的人阅读。