Drug Transporters pdf epub mobi txt 电子书下载 2026

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出版者:John Wiley & Sons Inc

作者:You, Guofeng/ Morris, Marilyn E./ Wang, Binghe

出品人:

页数:890

译者:

出版时间:2007-8

价格:1428.00 元

装帧:HRD

isbn号码:9780471784913

丛书系列:

图书标签:

药物转运体
药物代谢
药物动力学
生物利用度
细胞膜转运
转运蛋白
药物研发
药代动力学
药物吸收
药物排泄

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具体描述

A comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body The development of powerful expression cloning and genome analysis techniques has facilitated the molecular identification and characterization of numerous transporters that play a crucial role in drug disposition. Explaining the principles of drug transport and the associated techniques, Drug Transporters: Molecular Characterization and Role in Drug Disposition: Provides a comprehensive overview of drug transporters Includes specific descriptions of transporter families, including substrate and inhibitor specificity, subcellular and tissue localization, mechanisms governing transport, species differences, the clinical implications of these transporters in human physiology and disease, and their role in drug distribution, elimination, and interactions in drug therapy Describes transporter-mediated drug disposition, a newly emerging field in drug therapy Gives a comprehensive summary of drug transport across biological membranes in the liver, brain, kidney, and intestine Provides balanced coverage of mechanistic aspects and functional outcomes Features chapters contributed by distinguished scientists in their specialty areas Provides sufficient detail to enable non-specialists to understand the principles and techniques This authoritative guide is a practical hands-on desk reference for researchers in academia and the pharmaceutical industry and scientists in government agencies. It is also an excellent text for graduate-level courses in the pharmaceutical and pharmacology fields.

Drug Transporters是一本深入浅出的科学著作，旨在为读者提供全面而详实的信息。书中系统地介绍了药物如何通过各种运输机制进入和转运体内细胞的过程，这对于理解药物代谢、吸收与效果具有重要意义。这本书不仅涵盖了药物在生物体内的基本行为，还探讨了不同运输蛋白家族在生理和病理条件下的功能变化。书中详细描述了多种药物的运输方式，包括被动扩散、主动运输、载体介导转运和通道蛋白机制。这些内容帮助读者理解药物如何跨越细胞膜与不同组织，确保其在有效剂量下发挥作用。同时，书籍也介绍了一些特定于某些疾病状态下的运输变化，如肝脏疾病、肾功能不全等情况，这为临床诊断和治疗提供了有价值的参考依据。 Drug Transporters还详细论述了药物在生物系统中的相互作用，特别是它们与代谢酶、转运体的协同作用。这种多层次的分析让读者能够全面掌握药物在复杂生理环境中的行为模式和机制，为进一步研究和实际应用奠定坚实基础。书中通过丰富的图示和案例分析，帮助读者直观理解复杂的分子过程，并解释这些过程对临床治疗的重要影响。这本著作不仅适合医学生、药理学专业人员，也为药企研究人员和药物开发团队提供了有益的参考资料。书中内容经过精心编排，旨在提升读者对药物运输机制的认知，从而更好地制定合理的治疗方案，提高医疗服务质量。整个书籍通过严谨的科学论述和详细的解释，使复杂的生物学现象易于理解，同时不失学术性，真正满足专业读者的学习需求。 Drug Transporters以其详尽的内容和深入浅出的呈现方式，帮助读者全面掌握药物运输相关的知识，成为一本极具参考价值的科学书籍。在专业领域应用广泛，能有效支持临床研究与科研进程。通过系统性的学习与分析，这本书不仅丰富了对药物作用机制的理解，还为未来的创新治疗提供了思路。总的来说，它是一部兼顾理论深度和实际应用价值的高质量学术著作。