Genetic Control of Neuronal Migrations in Human Cortical Development 在线电子书 pdf 下载 txt下载 epub 下载 mobi 下载 2024

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Meyer, Gundela 作者

Springer Verlag

译者

出版日期

111 页数

$ 179.67 价格

Pap

丛书系列

9783540366881 图书编码

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发表于2024-11-25

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Genetic Control of Neuronal Migrations in Human Cortical Development 在线电子书 epub 下载 mobi 下载 pdf 下载 txt 下载 2024

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The early steps in corticogenesis are decisive for the correct unfolding of neurogenesis, neuronal migration and differentiation under tight genetic control. In this monograph, the author outlines the main events in human preplate formation, the gradual transformation of the preplate into the cortical plate, and the establishment of the transient compartments of the foetal cortical wall. The main neuronal populations of the embryonic and foetal cortex are presented according to their timetable of appearance and the expression of developmentally relevant gene products, with the main focus on members of the Reelin-Dab1 signalling pathway, LIS1 and Doublecortin, all of which are crucial for cortical migration. The often significant developmental differences between the lissencephalic rodent brain, which has become the prevailing model of corticogenesis, and the highly differentiated, gyrated human brain are pointed out and discussed.

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