Pharmacology of Neurotransmitter Release 在线电子书 pdf 下载 txt下载 epub 下载 mobi 下载 2024

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T. Sudhof, K. Starke 作者

Springer

译者

2008 出版日期

596 页数

$ 541.27 价格

丛书系列

9783540748045 图书编码

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Pharmacology of Neurotransmitter Release 在线电子书 epub 下载 mobi 下载 pdf 下载 txt 下载 2024

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Pharmacology of Neurotransmitter Release 在线电子书 pdf 下载 txt下载 epub 下载 mobi 在线电子书下载

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It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. This includes a discussion of presynaptic calcium channels, the core proteins of the secretory machinery, and the actions of clostridial toxins and a -latrotoxin, famous for their potency as well as their crucial role in the elucidation of the steps of exocytosis. In the booka (TM)s second part, the presynaptic receptors for endogenous chemical signals are presented that make neurotransmitter release a highly regulated process. These include ligand-gated ion channels and presynaptic G-protein-coupled receptors. The targets of presynaptic receptors within the exocytosis cascade, and their therapeutic potential, are subjects addressed in the majority of chapters.

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