This volume focuses on the innovative application of scientific and engineering fundamentals to issues of importance in biotechnology. The increasingly sophisticated use of tools in modern biology， coupled with engineering expertise， has significantly expanded the horizons of this discipline in recent years. New areas of investigation include biodiversity and its potential significance in biotechnology， tissue engineering， bioremediation， and aspects of antibody use and production. The technical information presented in this text reflects the impact of research advances along these lines. The 38 papers contained in this volume were presented at a conference sponsored by the Engineering Foundation， on 11-16th July， 1993， in Princeton， New Jersey， USA.
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