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Elastic Filaments of the Cell (Advances in Experimental Medicine and Biology) 在線電子書 pdf 下載 txt下載 epub 下載 mobi 下載 2024

Elastic Filaments of the Cell (Advances in Experimental Medicine and Biology)
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Granzier, Henk; Pollack, Gerald H.; Granzier, H. L. 作者
Springer
譯者
2000-08-31 出版日期
436 頁數
USD 275.00 價格
Hardcover
叢書系列
9780306464102 圖書編碼

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Elastic Filaments of the Cell (Advances in Experimental Medicine and Biology) 在線電子書 epub 下載 mobi 下載 pdf 下載 txt 下載 2024

Elastic Filaments of the Cell (Advances in Experimental Medicine and Biology) 在線電子書 epub 下載 pdf 下載 mobi 下載 txt 下載 2024

Elastic Filaments of the Cell (Advances in Experimental Medicine and Biology) 在線電子書 pdf 下載 txt下載 epub 下載 mobi 下載 2024


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Elastic Filaments of the Cell (Advances in Experimental Medicine and Biology) 在線電子書 著者簡介

Elastic Filaments of the Cell (Advances in Experimental Medicine and Biology) 在線電子書 著者簡介

Elastic Filaments of the Cell (Advances in Experimental Medicine and Biology) 在線電子書 pdf 下載 txt下載 epub 下載 mobi 在線電子書下載

Elastic Filaments of the Cell (Advances in Experimental Medicine and Biology) 在線電子書 圖書描述

Elastic filaments refer mainly to titin, the largest of all known proteins. Titin was discovered initially in muscle cells, where it interconnects the thick filament with the Z-line. Titin forms a molecular spring that is responsible for maintaining the structural integrity of contracting muscle, ensuring efficient muscle contraction. More recently, it has become clear that titin is not restricted to muscle cells alone. For example, titin is found in chromosomes of neurons and also in blood platelets. This topic is fast becoming a focal point for research in understanding viscoelastic properties at the molecular, cellular, and tissue levels. In titin may lie a generic basis for biological viscoelasticity. It has become clear that titin may hold the key to certain clinical anomalies. For example, it is clear that titin-based ventricular stiffness is modulated by calcium and that titin is responsible for the altered stiffness in cardiomyopathies. It is also clear from evidence from a group of Finnish families that titin mutations may underlie some muscular dystrophies and that with other mutations chromatids fail to separate during mitosis. Thus, it is clear that this protein will have important clinical implications stemming from its biomechanical role. One aspect of this field is the bringing together of bioengineers with clinical researchers and biologists. Genetic and biochemical aspects of titin-related proteins are being studied together with front-line engineering approaches designed to measure the mechanics of titin either in small aggregates or in single molecules.

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