Complex Enzymes in Microbial Natural Product Biosynthesis, Part A 在线电子书 pdf 下载 txt下载 epub 下载 mobi 下载 2024

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Hopwood, David A. 编作者

译者

2009-5 出版日期

350 页数

$ 224.87 价格

丛书系列

9780123745880 图书编码

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Complex Enzymes in Microbial Natural Product Biosynthesis, Part A 在线电子书 epub 下载 mobi 下载 pdf 下载 txt 下载 2024

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Complex Enzymes in Microbial Natural Product Biosynthesis, Part A 在线电子书 pdf 下载 txt下载 epub 下载 mobi 在线电子书下载

Complex Enzymes in Microbial Natural Product Biosynthesis, Part A 在线电子书图书描述

Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine. This title gathers tried and tested methods and techniques from top players in the field. It features in-depth coverage of ribosomally-synthesised and Non-ribosomally-synthesised peptides. It provides an extremely useful reference for the experienced research scientist.

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