The 23 articles in the 2008 edition of the annual series review recent findings in the study of biological function, organization, and structure by physical and physicochemical ideas and methods. A particularly lengthy chapter systemizes the role of intrinsically disordered proteins in cancer, Alzheimer's disease. Prion diseases, and type II diabetes. Other topics include mediation and modulation of membrane-cytoskeleton interactions, metal binding affinity and selectivity in metalloproteins, translocation and unwinding mechanisms of RNA and DNA helicases, and the structure of eukaryotic RNA polymerases.
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