Discover the links between infection with pathogenic microorganisms and such chronic illnesses as cancer, paralysis, arthritis, peptic ulcer, cirrhosis, and neurological disorders. Written and edited by leading experts, this bookt reviews the mechanisms used by pathogens to infect mucous surfaces, enter and multiply in the host environment, interfere with host defenses, damage host tissues, and produce long-term consequences. The text also explores the genetic and immunological status of afflicted individuals in terms of infection, disease progression, symptoms, and treatment options. The first chapter examines the difficulties in establishing critical links between an infectious etiology and a chronic illness. The next group of chapters explores diseases in which the evidence points to a specific bacterium, parasite, virus, fungus, or prion as the cause. There is also a chapter dedicated to diseases suspected of having an underlying infectious etiology, but for which no specific pathogen has been identified. Another chapter discusses epidemiological methods for confirming, refuting, or modifying the links between specific microorganisms and the complications and long-term consequences they cause. The final chapter examines the economic burden associated with the sequelae of infectious agents and suggests future directions for research. This text fills a critical void in the scientific literature, offering evidence of the causal links between infectious agents and chronic disorders and, most importantly, stimulating new research in this area. The book offers new insights for anyone involved in the diagnosis, treatment, prevention, and study of infectious disease. It is a recommended graduate-level text, providing students with a deep understanding of the mechanisms of host-pathogen interactions. Key Features* Provides a unique, single source dedicated to the sequelae and long-term consequences of infection by microbial pathogens* Elucidates the many mechanisms that microorganisms use to cause disease* Explores a variety of chronic illnesses known or suspected to be caused by bacteria, viruses, fungi, parasites, and prions* Serves as a springboard for new research into the causes of chronic illnesses as well as cures and preventive measures* Enables both specialists and non-specialists to bring themselves up to date on the latest evidence and open questions