The Immune Synapse as a Novel Target for Therapy 在线电子书 pdf 下载 txt下载 epub 下载 mobi 下载 2024

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Graca, Luis 编作者

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192 页数

$ 190.97 价格

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9783764382957 图书编码

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发表于2024-11-24

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The Immune Synapse as a Novel Target for Therapy 在线电子书 epub 下载 mobi 下载 pdf 下载 txt 下载 2024

The Immune Synapse as a Novel Target for Therapy 在线电子书 pdf 下载 txt下载 epub 下载 mobi 下载 2024

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The immune synapse can be compared to a molecular machine that controls T cell activation when getting in contact with an antigen-presenting cell (APC). The immune synapse is involved in the transfer of information across the T cell-APC junction. It plays an essential role in the control and nature of the immune response. In recent years several approaches have been developed to reprogramming the immune response by targeting molecules involved in the immune synapse. Monoclonal antibodies, such as the ones targeting the lymphocyte co-receptor, co-stimulatory and adhesion molecules (CD3, CD4, CD40L, CTLA4-Ig, ICAM-1), or altered peptide ligands have been shown capable of inducing immune tolerance in transplantation, autoimmunity and allergy. This volume gives an overview on the progress in the field, from basic science to clinical trials, and the major mechanisms involved. It discusses how interfering with T cell activation may lead to immune tolerance, immune modulation and the recruitment of regulatory T cells, the role of monoclonal antibodies in tolerance induction, and mechanisms maintaining dominant tolerance. The book is of interest to clinicians and researchers working in this area.

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