Innovative Drug Development for Headache Disorders pdf epub mobi txt 电子书下载 2026

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出版者:

作者:Olesen, Jes (EDT)/ Ramadan, Nabih (EDT)

出品人:

页数:240

译者:

出版时间:2008-11

价格:$ 230.52

装帧:

isbn号码:9780199552764

丛书系列:

图书标签:

Headache
Drug Development
Neurology
Pharmacology
Clinical Trials
Pain Management
Migraine
Tension-type Headache
Cluster Headache
Neuroscience

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具体描述

Migraine treatment improved considerably with the advent of the 'triptans' in the 1990s. While the drugs used previously for headache treatment had efficacy, some compounds had bothersome side effects and their overuse could lead to severe complications. In the early days of the triptans, it was widely presumed that migraine was no longer a treatment problem. However, it has gradually been recognized that a significant proportion of patients are not responsive to triptans or do not tolerate them. It is now clear that, even with effective treatment, patients with frequent migraine attacks are not treated well exclusively with acute medications. This is partly because patients are still bothered by the attacks and partly because frequent intake of acute medication may result in medication-overuse headache. These problems have led to a renewed interest in preventive migraine drugs.Part of the Frontiers in Headache Research series, this book summarizes the several promising new avenues for the development of future drugs for the treatment of migraine, including cortical-spreading depression inhibition, nitric oxide synthase inhibition and calcitonin gene-related peptide (CGRP) receptor antagonism, as well as other potential targets. The book presents frontline knowledge of these evolving modalities as far as it is available in the public domain. It is hoped that readers and their patients will find it exciting to learn about all the novel possibilities, and also that the impressive research advances in migraine will lead to increased funding, not only of migraine but also of other types of headache.

这本书深入探讨了头痛障碍治疗领域的最新进展，旨在为研究者、医药从业者以及相关医学领域的读者提供全面的理论支持和实用指南。它系统地回顾了头痛的类型及其生物学基础，从神经生理机制到血管变化，再到遗传因素等多个角度进行分析。书中详细描述了常见头痛形式，如紧张性头痛、片状头痛和偏头痛，并对每种类型的特征、成因及临床表现进行深入剖析。此外，作者还引入了现代研究方法，介绍了先进的诊断工具与技术的发展，包括脑影像学分析、基因检测以及分子诊疗手段，这些新兴技术为精准化治疗提供了重要保障。这些内容不仅帮助读者理解现有治疗方案的局限性，也指出了未来可能突破的方向。书中还广泛涉及临床应用与个体化治疗策略，探讨了药物开发的新路径，如靶向疗法、免疫调节剂以及新型药剂递送系统。这些信息对医生和药理学家在实际诊疗过程中具有重要的指导意义。同时，书中还关注了头痛患者的生活质量管理与心理支持的重要性，为整体健康提供有价值的建议。对于学术研究，作者详细阐述了头痛研究的最新进展，包括大数据分析、临床试验设计以及跨学科合作的必要性。这些内容不仅为科研人员提供参考资料，也强调了科学探索中的综合方法。书中还提到未来可能的发展趋势，如人工智能在头痛诊断与预测中的应用，以及更多个性化治疗方案的探索，显示出该领域持续不断的创新动力。整体而言，该书不仅聚焦于理论知识的全面梳理，更注重其实践价值，为读者提供了一份综合性的学习与应用指南。内容丰富、逻辑清晰，适合为专业人士和学生深入理解头痛障碍的复杂性及应对策略。这本书体现了医学研究的严谨性与前瞻性，值得各界读者深入阅读。