Medicinal Chemistry 在線電子書 pdf 下載 txt下載 epub 下載 mobi 下載 2024


Medicinal Chemistry

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Nogrady, Thomas/ Weaver, Donald F./ Nogrady, th 作者
Oxford Univ Pr
譯者
2005-8 出版日期
664 頁數
$ 118.65 價格
HRD
叢書系列
9780195104554 圖書編碼

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Medicinal Chemistry 在線電子書 epub 下載 mobi 下載 pdf 下載 txt 下載 2024

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Medicinal Chemistry 在線電子書 pdf 下載 txt下載 epub 下載 mobi 在線電子書下載

Medicinal Chemistry 在線電子書 圖書描述

Fully updated and rewritten by a basic scientist, who is also a practising physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and biochemical principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, "Medicinal Chemistry" examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then, it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and exogenous pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modelling techniques, high throughput screening, neurpharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.

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