Proteasome Inhibitors in Cancer Therapy 在线电子书 pdf 下载 txt下载 epub 下载 mobi 下载 2024

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Adams, Julian (EDT) 作者

Humana Pr Inc

译者

出版日期

328 页数

$ 175.15 价格

HRD

丛书系列

9781588292506 图书编码

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发表于2024-11-10

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Proteasome Inhibitors in Cancer Therapy 在线电子书 epub 下载 mobi 下载 pdf 下载 txt 下载 2024

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Proteasome Inhibitors in Cancer Therapy 在线电子书图书描述

A panel of leading academic and pharmaceutical investigators takes stock of the remarkable work that has been accomplished to date with proteasome inhibitors in cancer, and examines emerging therapeutic possibilities. The topics range from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of current clinical trials underway. The discussion of rationales for testing proteasome inhibitors in cancer models covers the role of the proteasome in NF-kB activation, the combining of conventional chemotherapy and radiation with proteasome inhibition, notably PS-341, new proteasome methods of inhibiting viral maturation, and the role of protesome inhibition in the treatment of AIDS. The authors also document the development of bortezomib (Velcadea" ) in Phase I clinical trials and in a multicentered Phase II clinical trials in patients with relapsed and refractory myeloma.

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