The Gene

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Siddhartha Mukherjee is the author of The Emperor of All Maladies: A Biography of Cancer, winner of the 2011 Pulitzer Prize in general nonfiction, and The Laws of Medicine. He is the editor of Best Science Writing 2013Mukherjee is an assistant professor of medicine at Columbia University and a cancer physician and researcher. A Rhodes scholar, he graduated from Stanford University, University of Oxford, and Harvard Medical School. He has published articles in Nature, The New England Journal of Medicine, The New York Times, and Cell. He lives in New York with his wife and daughters.

出版者:Scribner
作者:Siddhartha Mukherjee
出品人:
页数:608
译者:
出版时间:2016-5-17
价格:USD 32.00
装帧:Hardcover
isbn号码:9781476733500
丛书系列:
图书标签:
  • 科普 
  • 基因 
  • 生物 
  • 医学 
  • 英文原版 
  • 生物学 
  • 遗传学 
  • biology 
  •  
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From the Pulitzer Prize-winning, bestselling author of The Emperor of All Maladies—a magnificent history of the gene and a response to the defining question of the future: What becomes of being human when we learn to “read” and “write” our own genetic information?

The extraordinary Siddhartha Mukherjee has a written a biography of the gene as deft, brilliant, and illuminating as his extraordinarily successful biography of cancer. Weaving science, social history, and personal narrative to tell us the story of one of the most important conceptual breakthroughs of modern times, Mukherjee animates the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.

Throughout the narrative, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—cuts like a bright, red line, reminding us of the many questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In superb prose and with an instinct for the dramatic scene, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome.

As The New Yorker said of The Emperor of All Maladies, “It’s hard to think of many books for a general audience that have rendered any area of modern science and technology with such intelligence, accessibility, and compassion…An extraordinary achievement.” Riveting, revelatory, and magisterial history of a scientific idea coming to life, and an essential preparation for the moral complexity introduced by our ability to create or “write” the human genome, The Gene is a must-read for everyone concerned about the definition and future of humanity. This is the most crucial science of our time, intimately explained by a master.

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读后感

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An epic book about the past, present and future of gene research and application. Another dictionary-sized book. Filled with interesting stories and anecdotes about the history of gene research, it also raises serious ethical questions on its future: Can hu...  

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人类的完美性与脆弱性均隐藏在DNA分子的编码中:只要我们学会操纵这种化学物质,那么我们将能够改写自然、治愈疾病、改变命运并且重塑未来。 ——第二部分第六章:DNA双螺旋 【当人,而非人之外的事物或某个人,成为神,具有了神的创造和毁灭力量,那时候,人的造神运动才会停...  

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本文首发于《北京青年报》: 在我读中学的时候,学习到涉及微观领域的地方总是感觉很神奇,而且难以理解。如果是探索宇宙,它浩大,但是也给你脑力可以相见的空间。但是微观领域呢,一些看不见的“小球”构成了这个世界?或者,一些化学物质组成的基因,决定了我们行为特征,甚...  

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本文首发于《北京青年报》: 在我读中学的时候,学习到涉及微观领域的地方总是感觉很神奇,而且难以理解。如果是探索宇宙,它浩大,但是也给你脑力可以相见的空间。但是微观领域呢,一些看不见的“小球”构成了这个世界?或者,一些化学物质组成的基因,决定了我们行为特征,甚...  

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人类从来没有像今天这样无限接近生命的真相,当我们能够掌控和改造人类基因时,“人类”的概念也许将从根本上发生改变,后人类时代正在来临。《基因传》所讲的故事,与每个人都息息相关。 到底是什么力量或机制才能解释人类个体截然不同的命运与选择呢?人们在18 世纪之前曾经...  

用户评价

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出版社送了一本书,要写个短评。书很好,等不及翻译就看完了。《癌症传》的作者新著,厚的像词典,厚有厚的道理,可以说是最全的基因科普书了,从亚里士多德一路写到去年的研究成果,中间涵盖了几乎任何跟遗传学相关的重要内容。包括进化论、优生学、表观遗传,孟德尔的豌豆,摩尔的果蝇,人类基因草图,基因合成人胰岛素,变性,基因筛查和基因疗法。一路下来,你会看到西方一开始就从细处入手,哪怕在公元前,没有任何技术条件,亚里士多德们就在思索父母的特征是怎么传递给下一代的。虽然他们的假象极其幼稚,但就是这种直接的思维,带来可证伪的具体结论,进而实现不断进步。不像某医学,说什么心属火,肝属木,虚头八脑没法验证,说了几千年,还在原地踏步,还要死灰复燃,真是害人精。

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现代科学就是把东西打破,在组合起来的过程

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从门德尔植物园的豌豆到美国二十年代的优生学实践,从Paul Berg与学生们在Venus castle的饮酒对谈到遭遇失败的基因修改实践,Mukherjee的基因编年史用一种荡气回肠的方式自由的穿过自然科学研究与社会生活的隐形鸿沟。这在里,作为读者,我们看得见学者的坚韧,尊严,或者孤傲,也感受得到一门科学如何在各方力量的裹挟缠斗中寻求新的突破。

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条理清楚,简单明了,文笔也好。其中有几段关于基因学发展史以及基因与人类历史相互作用的文字真是怎么读都不厌。2018年的第一本书,非常值得。

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现代科学就是把东西打破,在组合起来的过程

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