DNA, Words and Models 在线电子书 pdf 下载 txt下载 epub 下载 mobi 下载 2024

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Robin, Stephane/ Rodolphe, Francois/ Schbath, Sophie 作者

Cambridge Univ Pr

译者

2005-10 出版日期

158 页数

$ 102.83 价格

HRD

丛书系列

9780521847292 图书编码

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发表于2024-11-08

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DNA, Words and Models 在线电子书 epub 下载 mobi 下载 pdf 下载 txt 下载 2024

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An important problem in computational biology is identifying short DNA sequences (mathematically, 'words') associated to a biological function. One approach consists in determining whether a particular word is simply random or is of statistical significance, for example, because of its frequency or location. This book introduces the mathematical and statistical ideas used in solving this so-called exceptional word problem. It begins with a detailed description of the principal models used in sequence analysis: Markovian models are central here and capture compositional information on the sequence being analysed. There follows an introduction to several statistical methods that are used for finding exceptional words with respect to the model used. The second half of the book is illustrated with numerous examples provided from the analysis of bacterial genomes, making this a practical guide for users facing a real situation and needing to make an adequate procedure choice.

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