GTPases Regulating Membrane Targeting and Fusion 在线电子书 pdf 下载 txt下载 epub 下载 mobi 下载 2024

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Balch, W. E. (EDT)/ Der, Channing J. (EDT)/ Hall, Alan (EDT) 作者

Academic Pr

译者

2005-12 出版日期

912 页数

$ 224.87 价格

HRD

丛书系列

9780121828080 图书编码

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GTPases Regulating Membrane Targeting and Fusion 在线电子书 epub 下载 mobi 下载 pdf 下载 txt 下载 2024

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GTPases Regulating Membrane Targeting and Fusion 在线电子书图书描述

Rab GTPases now comprise a family of >63 members. They are emerging as the key hub element controlling the membrane architecture of eukaryotic cells. They are intimately involved in vesicle targeting and fusion in both the endocytic and exocytic pathways and direct the assembly and disassembly of protein complexes that include regulators (GEFs and GAPs), effectors (tethers/motors) and fusion components (SNAREs) that control membrane targeting and fusion. During the last 3 years the field has virtually exploded with the identification and characterization of many new Rab proteins and their effectors. Our understanding of how Rab GTPases control membrane function remains at its infancy. This volume of MIE provides a wealth of new concepts, approaches and tools to study Rab proteins in the test tube and in living cells that will be of strong benefit to both established laboratories and new investigators in the field to elucidate Rab GTPase function in cellular development, differentiation and proliferation. It provides a comprehensive overview of Rab GTPase phylogeny and systems biology. It covers identification and characterization of Rab GEFs, GAPs and effectors. It offers general methodologies to study Rab GTPase function in vitro and in vivo using biochemical, molecular and microscopy approaches.

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