Protein Crystallography in Drug Discovery 在线电子书 pdf 下载 txt下载 epub 下载 mobi 下载 2024

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Mannhold, Raimund 作者

John Wiley & Sons Inc

译者

出版日期

278 页数

$ 195.00 价格

HRD

丛书系列

9783527306787 图书编码

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发表于2024-11-27

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Protein Crystallography in Drug Discovery 在线电子书 epub 下载 mobi 下载 pdf 下载 txt 下载 2024

Protein Crystallography in Drug Discovery 在线电子书 pdf 下载 txt下载 epub 下载 mobi 下载 2024

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Protein Crystallography in Drug Discovery 在线电子书 pdf 下载 txt下载 epub 下载 mobi 在线电子书下载

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The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included. A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.

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