DNA Topoisomerases in Cancer Therapy 在线电子书 pdf 下载 txt下载 epub 下载 mobi 下载 2024

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Andoh, Toshiwo 编作者

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2003-6 出版日期

214 页数

$ 168.37 价格

丛书系列

9780306477447 图书编码

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发表于2024-11-13

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DNA Topoisomerases in Cancer Therapy 在线电子书 epub 下载 mobi 下载 pdf 下载 txt 下载 2024

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In the mid 80's, type I and II enzymes were found to be the intracellular targets of a number of efficacious anticancer drugs such as doxorubicin, mitoxantrone, etoposide and camptothecin as a result of a continued efforts of many investigators, especially Leroy Liu and his collaborators at Johns Hopkins University. Readers will find a series of chapters written by researchers actively engaged in the expanding field of topoisomerase and their inhibitors. The series of chapters cover review articles on pharmacology and the molecular mechanism of topoisomerase I- and II-targeting anticancer drugs in mammals and in the yeast Saccharomyces cerevisiae, which has proved to be a superb model organism for studies of anticancer drugs. This volume compiles up-to-date information on the topoisomerase-targeting compounds in clinical and preclinical development as a useful and important reference book for students and researchers in the field of pharmacology, toxicology, oncology and molecular biology.

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