Selective Estrogen Receptor Modulators 在线电子书 pdf 下载 txt下载 epub 下载 mobi 下载 2024

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Manni, Andrea (EDT)/ Verderame, Michael (EDT) 作者

译者

2002-1 出版日期

384 页数

$ 281.37 价格

丛书系列

9780896039124 图书编码

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发表于2024-11-10

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Selective Estrogen Receptor Modulators 在线电子书 epub 下载 mobi 下载 pdf 下载 txt 下载 2024

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Experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs. The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of co-activators and co-repressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. The clinical presentation reviews the data accumulated on currently available SERMs, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. A tentative approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer.

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