Ion channels underlie a broad range of the most basic biological processes, from excitation and signaling to secretion and absorption. Like enzymes, they are diverse and ubiquitous macromolecular catalysts with high substrate specificity and subject to strong regulation. This fully revised and expanded Third Edition of Ion Channels of Excitable Membranes describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. It includes new chapters on calcium signaling, structural biology, and molecular biology and genomics. Ion Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ion Channels of Excitable Membranes is written to be accessible and interesting to life scientists and physical scientists of all kinds. It introduces all the concepts that a graduate student should be aware of but is also effective in advanced undergraduate courses. It has long been the recognized authoritative overview of this field used by all neuroscientists.
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The classical one for basic knowledge of ion channels.
评分導師帶著讀瞭一半瞭。前九章的生物學例子很經典值得背誦。第十章的經典電化學理論深入淺齣,適閤新手。希望今年能夠讀完第一遍。在博士後時期再讀一遍。
评分導師帶著讀瞭一半瞭。前九章的生物學例子很經典值得背誦。第十章的經典電化學理論深入淺齣,適閤新手。希望今年能夠讀完第一遍。在博士後時期再讀一遍。
评分導師帶著讀瞭一半瞭。前九章的生物學例子很經典值得背誦。第十章的經典電化學理論深入淺齣,適閤新手。希望今年能夠讀完第一遍。在博士後時期再讀一遍。
评分科學嚴謹,富於啓發性,絕對經典!
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