The hERG Cardiac Potassium Channel

The hERG Cardiac Potassium Channel pdf epub mobi txt 电子书 下载 2025

出版者:John Wiley & Sons Inc
作者:Novartis Foundation
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页数:297
译者:
出版时间:2005-4
价格:1310.80元
装帧:HRD
isbn号码:9780470021408
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This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding. It features regulatory authority perspectives on preferred preclinical test systems and includes topics on hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks. Better understanding of the role of the hERG channel in drug-induced cardiac arrhythmias should ultimately lead to the development of important, new and safer medicines.

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