The Death of Cancer

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出版者:Sarah Crichton Books
作者:Vincent T. DeVita
出品人:
页数:336
译者:
出版时间:2015-11-3
价格:USD 28.00
装帧:Hardcover
isbn号码:9780374135607
丛书系列:
图书标签:
  • 医学
  • 传记
  • 癌症
  • medicine
  • cancer
  • 科普
  • science
  • history
  • 癌症
  • 治疗
  • 科学
  • 医学
  • 健康
  • 研究
  • 生存
  • 希望
  • 疗法
  • 突破
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具体描述

Cancer touches everybody’s life in one way or another. But most of us know very little about how the disease works, why we treat it the way we do, and the personalities whose dedication got us where we are today. For fifty years, Dr. Vincent T. DeVita Jr. has been one of those key players: he has held just about every major position in the field, and he developed the first successful chemotherapy treatment for Hodgkin’s lymphoma, a breakthrough the American Society of Clinical Oncologists has called the top research advance in half a century of chemotherapy. As one of oncology’s leading figures, DeVita knows what cancer looks like from the lab bench and the bedside. The Death of Cancer is his illuminating and deeply personal look at the science and the history of one of the world’s most formidable diseases. In DeVita’s hands, even the most complex medical concepts are comprehensible.

Cowritten with DeVita’s daughter, the science writer Elizabeth DeVita-Raeburn, The Death of Cancer is also a personal tale about the false starts and major breakthroughs, the strong-willed oncologists who clashed with conservative administrators (and one another), and the courageous patients whose willingness to test cutting-edge research helped those oncologists find potential treatments. An emotionally compelling and informative read, The Death of Cancer is also a call to arms. DeVita believes that we’re well on our way to curing cancer but that there are things we need to change in order to get there. Mortality rates are declining, but America’s cancer patients are still being shortchanged―by timid doctors, by misguided national agendas, by compromised bureaucracies, and by a lack of access to information about the strengths and weaknesses of the nation’s cancer centers.

With historical depth and authenticity, DeVita reveals the true story of the fight against cancer. The Death of Cancer is an ambitious, vital book about a life-and-death subject that touches us all.

Review

“For the past half century, [DeVita] has been at the forefront of the fight against one of the world’s most feared diseases, and in The Death of Cancer he has written an extraordinary chronicle . . . his conclusions are deeply unsettling. . . DeVita’s portrait of the way things were gives us a glimpse at what the future may look like.” ―Malcolm Gladwell, The New Yorker

“In The Death of Cancer, Dr. DeVita (with his daughter Elizabeth DeVita-Raeburn) paints a portrait of a cancer industrial complex desperately in need of an overhaul, hampered by petty politics and power mongering, among much else . . . Powerful . . . There is no mistaking the value of the core idea he wants to convey: that doctors and researchers commit themselves anew to doing everything possible to help the patient.” ―The Wall Street Journal

“An authoritative review of the history of surgery and radiation therapy . . . Ultimately, DeVita ably shows that the development of oncology as a modern specialty is a very human story.” ―The New York Times Book Review

“This riveting, beautifully written, and poignant memoir takes us on an enormous journey―from cancer’s past to its future. Vincent T. DeVita Jr. brings us behind the scenes to the invention of breakthrough therapies for some forms of cancer in the 1960s and ’70s. He also provides a much-needed manifesto for the future.” ―SIDDHARTHA MUKHERJEE, Pulitzer Prize–winning author of The Emperor of All Maladies

“An utterly absorbing memoir, fierce and frank . . . [T]he average reader will come away from the book with a superb basic education in all things oncological, from events on the cellular level to those in the rooms where research agendas are settled and checks are written.” ―The New York Times

“A fascinating memoir … Siddhartha Mukherjee called his Pulitzer Prize winning “The Emperor of All Maladies’’ a “biography” of the disease. “The Death of Cancer’’ is its obituary. We’re at “the beginning of the end,” DeVita declares of the war on cancer.” ―The Boston Globe

“The Death of Cancer is an astonishingly good read. Written by a cancer expert who happens to be a cancer survivor as well, it deftly explains the treatments that have turned this insidious disease from a death sentence into a manageable chronic condition for millions of people―and what yet remains to be done. I devoured the book in two sittings, struck, page after page, by its insight, honesty, compassion, and plain common sense.” ―DAVID M. OSHINSKY, Pulitzer Prize–winning author of Polio: An American Story

“The Death of Cancer is a fascinating insider history of the long battle against one of the world’s most feared diseases, told with both insight and frustration, and ultimately with hope. This collaboration between the former National Cancer Institute director Vincent T. DeVita Jr. and his talented science writer daughter, Elizabeth DeVita-Raeburn, results in a wonderfully human portrait of the scientists who join the fight and a wonderfully smart look at the ways we might actually win it.” ―DEBORAH BLUM, New York Times–bestselling author of The Poisoner’s Handbook

“Superb science writing . . . One of the most absorbing and empowering science histories to hit the shelves in recent years.” ―Kirkus Reviews (starred review)

“DeVita blends crisp writing and a gift for explaining complicated scientific concepts clearly with deep knowledge, passion, and wit. The book is by turns entertaining and maddening, but always fascinating. Highly recommended” ―Library Journal (starred review)

"DeVita, an oncologist and professor at Yale School of Medicine, collaborates with his daughter DeVita-Raeburn on this engaging, informative, and inspiring history of DeVita’s prominent role in developing innovative cancer treatments . . . They also unveil some startling insights [and] offer salient advice . . . This remarkable memoir doesn’t just urge the public to have hope: it showcases the exciting evidence that we may finally be winning the war on cancer."

―Publishers Weekly (starred review)

"[A] straight-talking, optimistic memoir."

―Booklist

"An extraordinary book and an extraordinary story" ―Cancer Letter

《肿瘤战争:科学家的黎明》 内容梗概: 《肿瘤战争:科学家的黎明》是一部深入探讨人类与癌症斗争的史诗,它并非聚焦于单一的治疗突破,而是描绘了一幅宏大而精细的画卷,展现了科学家们如何在黑暗中摸索,如何用智慧和勇气点燃希望之光。本书追溯了癌症研究的漫长历程,从早期对疾病的懵懂认知,到如今对癌细胞复杂机制的深刻理解,每一个进步都凝聚了无数科学家的心血与汗水。 本书将带你走进实验室的深处,近距离观察那些不知疲倦的身影。你将看到生物化学家如何解构细胞信号通路,免疫学家如何激发人体自身的防御力量,遗传学家如何破解癌症的基因密码,以及药理学家如何巧妙地设计出靶向性的武器。这不是一个关于奇迹发生的童话,而是一部关于坚持、质疑、合作与牺牲的真实记录。 你将跟随作者的脚步,穿越不同的时代,遇见那些在关键时刻挺身而出的先驱者。从早期对显微镜下细胞形态的细致观察,到分子生物学革命带来的颠覆性认知,再到基因组学和大数据分析开启的精准医疗新纪元,《肿瘤战争:科学家的黎明》将为你一一呈现。书中不仅有成功的喜悦,更有无数次的失败和挫折,那些被搁浅的研究、被否定的理论、以及在无尽的实验中消耗的宝贵生命。 本书将重点剖析癌症研究中的几个核心战场: 细胞增殖的失控: 探索细胞周期调控的精妙机制,以及癌细胞如何绕过这些“刹车”机制,进行疯狂的自我复制。你将了解到信号转导通路中的关键节点,以及它们如何成为药物开发的靶点。 基因组的紊乱: 深入理解癌症发生的基因层面的原因,包括突变、染色体异常和表观遗传学的改变。本书将介绍基因测序技术如何帮助我们识别致癌基因和抑癌基因,为个体化治疗提供依据。 免疫系统的博弈: 揭示癌细胞如何学会伪装,躲避免疫系统的追捕。同时,你也将看到免疫疗法如何通过激活T细胞、NK细胞等免疫卫士,教会身体识别并摧毁癌细胞。 微环境的复杂性: 探讨肿瘤生长并非孤立的事件,而是与周围的血管、纤维组织、免疫细胞等形成一个复杂的“微环境”。理解这一环境如何影响肿瘤的生长、转移和对治疗的反应,是制定更有效策略的关键。 耐药性的挑战: 癌细胞的狡猾之处在于其不断进化的能力,常常会产生对现有疗法的耐药性。本书将探讨耐药性的产生机制,以及科学家们如何为此开发新的策略,例如联合疗法和药物递送系统。 《肿瘤战争:科学家的黎明》不仅是一部科学史,更是一部关于人性与希望的赞歌。它将引导读者理解癌症的复杂性,认识到治愈癌症绝非一蹴而就,而是需要持续不懈的科学探索和全球合作。书中将穿插对那些为了癌症研究奉献一生,甚至牺牲生命的科学家们的致敬,他们的故事将激励着新一代的研究者继续前行。 本书语言生动,即使是对科学不甚了解的读者,也能从中获得深刻的洞察。作者力求以通俗易懂的方式,解释复杂的科学概念,让读者感受到科学研究的魅力和前沿性。它将让你重新审视癌症,不再仅仅将其视为一种可怕的疾病,而是将其看作一个需要被深入理解和攻克的科学挑战。 《肿瘤战争:科学家的黎明》是一次对人类智慧与耐力最诚挚的致敬,它揭示了人类在面对未知时所展现出的非凡勇气,以及科学精神在探索生命奥秘道路上所扮演的关键角色。这本书将点燃你对科学的兴趣,对人类攻克癌症这一世纪难题的未来充满信心。

作者简介

Vincent T. DeVita Jr., M.D. is a professor of medicine, epidemiology, and public health at the Yale School of Medicine. He was the director of the National Cancer Institute and the National Cancer Program from 1980 to 1988. In 1988 he joined Memorial Sloan Kettering Cancer Center as the physician in chief. In 1993 he became the director of the Yale Cancer Center. At the NCI, he developed a cure for Hodgkin’s lymphoma with combination chemotherapy, proving that advanced cancers can be cured by drugs. He is a former president of the American Cancer Society and the coeditor of Cancer: Principles & Practice of Oncology, a textbook of cancer medicine.

Elizabeth DeVita-Raeburn has written about medicine, science, and psychology for many publications. She is the author of The Empty Room: Understanding Sibling Loss. She lives in New York City with her husband, the writer Paul Raeburn, and their two sons.

目录信息

Title Page
Copyright Notice
Dedication
Introduction
1. Outrageous Fortune
2. The Chemotherapists
3. MOMP
4. MOPP
5. The War on Cancer
6. Boots on the Ground
7. Cleaning House at the National Cancer Institute
8. Frances Kelsey Syndrome
9. Where Rubber Meets the Road
10. The Death of Cancer
11. Outrageous Fortune Part II
Notes
Acknowledgments
Index
Photographs
A Note About the Authors
Also by Vincent T. DeVita Jr., M.D., and Elizabeth DeVita-Raeburn
Copyright
· · · · · · (收起)

读后感

评分

2015年年底,Vincent DeVita 教授在81岁高龄,出版了了他的自传《The Death of Cancer》,全名是 The Death of Cancer: After Fifty Years on the Front Lines of Medicine, a Pioneering Oncologist Reveals Why the War on Cancer Is Winnable--and How We Can Get There。De...

评分

2015年年底,Vincent DeVita 教授在81岁高龄,出版了了他的自传《The Death of Cancer》,全名是 The Death of Cancer: After Fifty Years on the Front Lines of Medicine, a Pioneering Oncologist Reveals Why the War on Cancer Is Winnable--and How We Can Get There。De...

评分

2015年年底,Vincent DeVita 教授在81岁高龄,出版了了他的自传《The Death of Cancer》,全名是 The Death of Cancer: After Fifty Years on the Front Lines of Medicine, a Pioneering Oncologist Reveals Why the War on Cancer Is Winnable--and How We Can Get There。De...

评分

2015年年底,Vincent DeVita 教授在81岁高龄,出版了了他的自传《The Death of Cancer》,全名是 The Death of Cancer: After Fifty Years on the Front Lines of Medicine, a Pioneering Oncologist Reveals Why the War on Cancer Is Winnable--and How We Can Get There。De...

评分

2015年年底,Vincent DeVita 教授在81岁高龄,出版了了他的自传《The Death of Cancer》,全名是 The Death of Cancer: After Fifty Years on the Front Lines of Medicine, a Pioneering Oncologist Reveals Why the War on Cancer Is Winnable--and How We Can Get There。De...

用户评价

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这本书的封面设计让我印象深刻,那种深邃的黑色背景上,一抹破晓的光芒试图挣脱黑暗的束缚,仿佛预示着一场艰巨但充满希望的斗争。我一直对医学领域的突破性进展非常感兴趣,尤其是那些能够触及人类最深层恐惧的疾病。虽然我尚未打开这本书,但单凭这个标题,就足以激发我无限的遐想。它并非一个简单的新闻报道,也不是一个冰冷的科学报告,而更像是一首关于勇气、牺牲与智慧的史诗。我脑海中浮现出无数科学家的身影,他们在实验室里无数个不眠之夜,在失败与挫折中一次次爬起,只为寻找那一线生机。我想象着那些在病魔面前顽强抗争的生命,他们的故事将如何被书写,他们的勇气又将如何被传颂。这本书,或许就是对人类智慧与生命力量的一次深情致敬,是对医学发展历程的一次深刻回溯,更是对未来无限可能的一次大胆眺望。它不仅仅是一本书的名字,更是一种精神的象征,一种对战胜绝望、拥抱希望的坚定信念的宣言。我迫不及待地想要翻开它,去感受那份沉甸甸的重量,去聆听那份震撼心灵的故事,去探寻那份关于“癌症消亡”的宏大愿景。

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从这本书的书名来看,我预感它将是一部极具前瞻性和思想深度的作品。我一直关注着科技发展对人类社会带来的深刻变革,而癌症作为人类健康的最大挑战之一,其“终结”无疑将是医学史上最伟大的里程碑。我相信,这本书绝非简单地罗列技术名词,而是会以一种引人入胜的方式,解读那些推动癌症研究进入新纪元的关键性发现。我猜测,作者可能会深入浅出地介绍基因编辑、免疫疗法、靶向药物等前沿技术,并分析它们是如何一步步瓦解癌症的堡垒。更重要的是,它或许会探讨这些科学突破是如何改变我们对生命、对衰老,甚至对人类命运的理解的。这本书,很可能是一份关于未来医疗蓝图的描绘,它将勾勒出一个我们或许从未想象过的健康生活图景,一个不再被癌症阴影笼罩的未来。我期待它能带我遨游在科学的海洋,领略那些最璀璨的智慧火花,并对人类未来的医学发展产生更深刻的认知和更美好的憧憬。

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我最近在书店里无意间瞥见了这本书,它散发出一种沉静而又充满力量的气息。作为一名对历史事件和人文关怀有着浓厚兴趣的读者,我立刻被它所吸引。我猜想,这本书一定不仅仅是关于医学的技术革新,更可能深入探讨了人类在面对重大疾病时的社会、伦理以及心理层面的复杂议题。它或许会追溯癌症研究的历史脉络,揭示那些被历史长河掩埋的早期探索,以及那些在黑暗时代里,科学家们如何凭借信念和毅力,一点点点亮科学的火种。我甚至可以想象,书中会穿插一些感人至深的患者故事,他们的经历不仅仅是医学上的挑战,更是对生命意义、家庭羁绊以及人性光辉的一次次拷问与升华。这本书,或许会成为一部关于人类群体如何共同面对一个共同的敌人,如何团结协作,如何牺牲奉献的史诗。它不仅仅是对科学成就的赞美,更是对人类文明进步的一次深刻反思,对那些在抗癌斗争中付出一切的无名英雄们的一次深情告白。我非常期待能从这本书中,看到一个更广阔的视角,理解癌症治疗背后的人性光辉和时代洪流。

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我喜欢那些能够引发深度思考的书籍,而《The Death of Cancer》这个名字,无疑具有这种魔力。它所蕴含的意义,远不止字面上的“癌症的死亡”,它或许代表着人类在与疾病的斗争中,一次具有划时代意义的胜利,一次对生命极限的重新定义。我猜想,这本书会以一种极其宏大的叙事方式,展开癌症研究的波澜壮阔的画卷。它可能不仅仅聚焦于最新的科学突破,更会追溯那些在历史长河中,一代代科学家们前赴后继的艰辛探索。我想象着,书中会详细描绘那些看似微不足道的实验,如何最终汇聚成改变人类命运的洪流。它或许会探讨,是什么样的科学精神、哲学思考,以及社会推动力,才让我们一步步走向治愈癌症的彼岸。这本书,不只是一部科学史,更是一部关于人类智慧、勇气和不屈不挠精神的赞歌。它激励着我们相信,即便是最顽固的敌人,也终将被人类的智慧和决心所征服。

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对于一本以“癌症的终结”为主题的书,我充满了一种复杂的情感——既有期待,也有好奇,更有对生命本身的敬畏。我不会将它仅仅视为一本科普读物,更倾向于认为它是一部关于人类与疾病斗争史诗的浓缩。我推测,作者将以一种人文主义的视角,去审视癌症研究的每一个里程碑。它或许会穿插一些鲜为人知的故事,讲述那些在实验室里默默奉献的科学家,以及那些在抗癌道路上顽强拼搏的生命。我想象着,书中会探讨,在科学技术飞速发展的背后,人类的情感、社会的支持以及哲学层面的思考,是如何共同推动着我们向着“无癌时代”迈进。这本书,很可能是一次对生命韧性的赞颂,一次对人类探索未知精神的礼赞,一次对未来充满无限希望的展望。它不仅能让我了解科学的进步,更重要的是,能让我感受到生命的力量,以及人类在面对挑战时所展现出的非凡勇气和智慧。

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回忆录式的写法,加上作者资历老、地位高、无论是和癌症还是和官僚体制的斗争经验都非常丰富,很多地方看似想起了就说一下却让人非常震撼。比如作者提到 1/50000 的药物成分经过筛选能进入1期临床,其中只有 1/5000 能显示出明显效果和足够的耐药性进入2期临床,这些进入2期临床的又只有 1/50 能真的经受住考验。绝大多数时候,你只是在1期临床碰到一堆没有治疗效果只有副作用的药物而已。

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比癌症更可怕的是庸医,保守的医生,与保守的监管体制

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"Now this is not the end. It is not even the beginning of the end. But it is, perhaps, the end of the beginning."

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比癌症更可怕的是庸医,保守的医生,与保守的监管体制

评分

回忆录式的写法,加上作者资历老、地位高、无论是和癌症还是和官僚体制的斗争经验都非常丰富,很多地方看似想起了就说一下却让人非常震撼。比如作者提到 1/50000 的药物成分经过筛选能进入1期临床,其中只有 1/5000 能显示出明显效果和足够的耐药性进入2期临床,这些进入2期临床的又只有 1/50 能真的经受住考验。绝大多数时候,你只是在1期临床碰到一堆没有治疗效果只有副作用的药物而已。

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