Mouse Models of Human Cancer pdf epub mobi txt 电子书下载 2026

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出版者:John Wiley & Sons Inc

作者:Holland, Eric C. 编

出品人:

页数:482

译者:

出版时间:2004-8

价格:270.00 元

装帧:HRD

isbn号码:9780471444602

丛书系列:

图书标签:

Cancer Research
Mouse Models
Oncology
Biomedical Research
Animal Models
Cancer Biology
Drug Discovery
Genetics
Molecular Biology
Preclinical Studies

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具体描述

Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize new imaging techniques, and test novel therapies. Recent developments along these lines show great promise for the development of new anti-cancer treatments. Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field. Offering a survey of the latest research and a description of future areas of interest, this text: Presents real experimental data Describes organ site-specific mouse models Clearly identifies suitable models for further drug testing Critically analyzes current methodologies and their limitations Features numerous recognizable expert contributors Lists key Web sites, reagents, and companies From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ-specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions. Combining stellar chapter authors, rich illustrations, and clear, up-to-date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting-edge researchers.

这本书全面系统地探讨了鼠模型在人类癌症研究中的广泛应用，它深入分析了不同类型肿瘤中使用小鼠实验的具体方法和设计。通过详细介绍研究者们如何建立科学、可重复的模型，读者可以了解这些模型在理解癌症发展过程中的重要性。书中涵盖了多种常见人类癌症，如乳腺癌、前列腺癌、肺癌以及多发性骨髓瘤等，并详细描述了相关实验设计、组织切片技术、细胞增殖实验及其与患者样本的对比分析。这不仅帮助读者认识各类模型在实际应用中的优缺点，还提供了研究方法的具体操作步骤。书籍还特别强调了不同研究场景下模型选择的重要性，例如选择合适的小鼠品种、实验阶段和癌症类型，以确保实验结果的可靠性与科学性。这部分内容尤其有助于初学者理解模型建立的关键要点，同时也为后续深入研究提供了坚实基础。书中还包含大量图示和案例分析，使复杂的实验过程变得直观易懂，增强了读者对模型使用的实际操作能力。此外，这本书不仅关注肿瘤生物学层面，还引入了分子机制、基因突变及其与癌症进展之间关系的探讨，为理解人类癌症的多样性提供了全新视角。通过这些详实而深入的内容，读者将获得对鼠模型在生命科学研究中的重要作用以及未来发展方向的全面认识。这本书适合希望深入了解癌症研究方法、科研人员及医学学生参考，其内容既专业又易于理解。总体来说，这本书以清晰的逻辑和系统的分析方式，完整地展示了鼠模型在人类癌症研究中的价值与意义，通过丰富的实例和详细的描述，使读者对该领域有更深刻的认知。它不仅是一个科学著作，更是一份引导未来探索的宝贵指南，适合不同背景的专业人士和爱好者共同学习。这篇详细阐述的简介旨在全面呈现图书内容，使读者能够清晰了解其核心价值，理解鼠模型在癌症研究中的重要地位，同时也为后续深入探讨提供坚实基础。