Mouse Models of Human Cancer pdf epub mobi txt 電子書下載2026

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出版者:John Wiley & Sons Inc

作者:Holland, Eric C. 編

出品人:

頁數:482

译者:

出版時間:2004-8

價格:270.00 元

裝幀:HRD

isbn號碼:9780471444602

叢書系列:

圖書標籤:

Cancer Research
Mouse Models
Oncology
Biomedical Research
Animal Models
Cancer Biology
Drug Discovery
Genetics
Molecular Biology
Preclinical Studies

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具體描述

Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize new imaging techniques, and test novel therapies. Recent developments along these lines show great promise for the development of new anti-cancer treatments. Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field. Offering a survey of the latest research and a description of future areas of interest, this text: Presents real experimental data Describes organ site-specific mouse models Clearly identifies suitable models for further drug testing Critically analyzes current methodologies and their limitations Features numerous recognizable expert contributors Lists key Web sites, reagents, and companies From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ-specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions. Combining stellar chapter authors, rich illustrations, and clear, up-to-date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting-edge researchers.

這本書全麵係統地探討瞭鼠模型在人類癌癥研究中的廣泛應用，它深入分析瞭不同類型腫瘤中使用小鼠實驗的具體方法和設計。通過詳細介紹研究者們如何建立科學、可重復的模型，讀者可以瞭解這些模型在理解癌癥發展過程中的重要性。書中涵蓋瞭多種常見人類癌癥，如乳腺癌、前列腺癌、肺癌以及多發性骨髓瘤等，並詳細描述瞭相關實驗設計、組織切片技術、細胞增殖實驗及其與患者樣本的對比分析。這不僅幫助讀者認識各類模型在實際應用中的優缺點，還提供瞭研究方法的具體操作步驟。書籍還特彆強調瞭不同研究場景下模型選擇的重要性，例如選擇閤適的小鼠品種、實驗階段和癌癥類型，以確保實驗結果的可靠性與科學性。這部分內容尤其有助於初學者理解模型建立的關鍵要點，同時也為後續深入研究提供瞭堅實基礎。書中還包含大量圖示和案例分析，使復雜的實驗過程變得直觀易懂，增強瞭讀者對模型使用的實際操作能力。此外，這本書不僅關注腫瘤生物學層麵，還引入瞭分子機製、基因突變及其與癌癥進展之間關係的探討，為理解人類癌癥的多樣性提供瞭全新視角。通過這些詳實而深入的內容，讀者將獲得對鼠模型在生命科學研究中的重要作用以及未來發展方嚮的全麵認識。這本書適閤希望深入瞭解癌癥研究方法、科研人員及醫學學生參考，其內容既專業又易於理解。總體來說，這本書以清晰的邏輯和係統的分析方式，完整地展示瞭鼠模型在人類癌癥研究中的價值與意義，通過豐富的實例和詳細的描述，使讀者對該領域有更深刻的認知。它不僅是一個科學著作，更是一份引導未來探索的寶貴指南，適閤不同背景的專業人士和愛好者共同學習。這篇詳細闡述的簡介旨在全麵呈現圖書內容，使讀者能夠清晰瞭解其核心價值，理解鼠模型在癌癥研究中的重要地位，同時也為後續深入探討提供堅實基礎。