Genetic Effects on Environmental Vulnerability to Disease 在线电子书 pdf 下载 txt下载 epub 下载 mobi 下载 2024

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Rutter, Sir Michael 编作者

译者

2008-8 出版日期

232 页数

795.00元价格

丛书系列

9780470777800 图书编码

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Genetic Effects on Environmental Vulnerability to Disease 在线电子书 epub 下载 mobi 下载 pdf 下载 txt 下载 2024

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Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. A gene-environment interaction approach assumes that environmental pathogens cause disorder, whereas genes influence susceptibility to environmental pathogens. This book brings together contributions from experts from multiple disciplines who discuss: How epidemiological cohort studies can better integrate physiological (mechanistic) measures; How best to characterise subjects’ vulnerability versus resilience by moving beyond single genetic polymorphisms; How gene hunters can benefit from recruiting samples selected for known exposures; How environmental pathogens can be used as tools for gene hunting; How to deal with potential spurious (statistical) interactions, and How genes can help explain fundamental demographic properties of disorders (e.g. sex distribution, age effects).

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