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Molecular Mechanisms of Parasite Invasion

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Burleigh, Barbara A., Ph.D. (EDT)/ Soldati-Favre, Dominique, Ph.D. (EDT) 作者
譯者
2008-4 出版日期
257 頁數
$ 292.67 價格
叢書系列
9780387782669 圖書編碼

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Molecular Mechanisms of Parasite Invasion 在線電子書 epub 下載 mobi 下載 pdf 下載 txt 下載 2024

Molecular Mechanisms of Parasite Invasion 在線電子書 epub 下載 pdf 下載 mobi 下載 txt 下載 2024

Molecular Mechanisms of Parasite Invasion 在線電子書 pdf 下載 txt下載 epub 下載 mobi 下載 2024



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Molecular Mechanisms of Parasite Invasion 在線電子書 pdf 下載 txt下載 epub 下載 mobi 在線電子書下載

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In biological terms, a parasite can be defined as 'an organism that grows, feeds and is sheltered on, or in, a different organism while contributing nothing to the survival of the host'. This relationship is particularly intimate for parasitic protozoa (and single-celled fungi such as the Microsporidia), many of which not only penetrate tissue barriers, but gain entry into host cells. The entry mechanisms are as diverse as the organisms employing them and are often critical components of their pathogenic profile. All of the parasitic organisms highlighted in this new book represent medically important human pathogens that contribute significantly to the global burden of disease. As such there is intense interest in understanding the molecular basis of infection by these pathogens - not only with regard to their clinical relevance but also the fascinating biology they reveal. For most of the parasites discussed here (Plasmodium falciparum, Toxoplasma gondii, Cryptosporidium parvum, Trypanosoma cruzi and Leishmania spp.) the ability to penetrate biological barriers and/or to establish intracellular residence is critical to survival of the pathogen in the mammalian hosts. For other parasites, such as Entamoeba, a tissue invasive phenotype is a key virulence determinant. In the ensuing 18 chapters, select members of this diverse set of protozoan parasites, as well as some examples of the extremely reduced fungal parasites classified as Microsporidia, are discussed within the context of the fascinating molecular strategies employed by these organisms to migrate across biological barriers and to establish residence within target host cells.

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