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OHOLO Conference on Blood-Brain Barrier 作者

译者

2002-2 出版日期

428 页数

$ 111.87 价格

丛书系列

9780306467080 图书编码

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发表于2024-09-21

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Blood Brain Barrier 在线电子书 epub 下载 mobi 下载 pdf 下载 txt 下载 2024

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Blood Brain Barrier 在线电子书图书描述

These proceedings review and discuss the different aspects of the biology of the Blood-Brain Barrier (BBB) and its involvement in the pathogenesis of brain disorders. The BBB, formed by a complex cellular system of endothelial cells, astroglia, pericytes, perivascular macrophages and a basal membrane, serves as a controlled functional gate to CNS. In vitro and in vivo models have been established to study the cellular and molecular interaction within the BBB and between the BBB and the neural cells. The structural and functional integrity of the BBB was shown to be dramatically altered during various diseases of the CNS, including neoplasia, ischemia, trauma, inflammation and bacterial and viral infections. Two approaches to drug delivery across the BBB have been pursued, based on either modulation of the permeability of the barrier or by conjugation of the drug to substrates of the active transport systems of the BBB.

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