Pharmacokinetic-Pharmacodynamic Modeling and Simulation 在线电子书 pdf 下载 txt下载 epub 下载 mobi 下载 2024

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Bonate, Peter L. 作者

Springer Verlag

译者

2005-10 出版日期

400 页数

$ 111.87 价格

HRD

丛书系列

9780387271972 图书编码

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Pharmacokinetic-Pharmacodynamic Modeling and Simulation 在线电子书 epub 下载 mobi 下载 pdf 下载 txt 下载 2024

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A natural hierarchy exists in pharmacokinetic-pharmacodynamic modeling culminating in population pharmacokinetic models, which are a specific type of nonlinear mixed effects model. The purpose of this book is to present through theory and example how to develop pharmacokinetic models, both at an individual and population level. In order to do so, however, one must first understand linear models and then build to nonlinear models followed by linear mixed effects models and then ultimately nonlinear mixed effects models. This book develops in that manner - each chapter builds upon previous chapters by first presenting the theory and then illustrating the theory using published data sets and actual data sets that were used in the development of new chemical entities collected by the author during his years in industry. A key feature of the book is the process of modeling. Most books and manuscripts often present the final model never showing how the model evolved. In this book all examples are presented in an evolutionary manner.

Pharmacokinetic-Pharmacodynamic Modeling and Simulation 在线电子书下载 mobi epub pdf txt 在线电子书下载

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