Physiologically based pharmacokinetic modeling生理学上基于药物动力学的建模在线电子书 pdf 下载 txt下载 epub 下载 mobi 下载 2024

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Reddy, Micaela B. (EDT)/ Yang, Raymond S. H., Ph.D. (EDT)/ Clewell, Harvey J., III (EDT)/ Andersen, 作者

John Wiley & Sons Inc

译者

2005-6 出版日期

420 页数

1085.00元价格

HRD

丛书系列

9780471478140 图书编码

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A definitive, single source of information on PBPK modeling

Physiologically-based pharmacokinetic (PBPK) modeling is becoming increasingly important in human health risk assessments and in supporting pharmacodynamic modeling for toxic responses. Organized by classes of compounds and modeling purposes so users can quickly access information, this is the first comprehensive reference of its kind.

This book presents an overview of the underlying principles of PBPK model development. Then it provides a compendium of PBPK modeling information, including historical development, specific modeling challenges, and current practices for:

* Halogenated Alkanes

* Halogenated Alkenes

* Alkene and Aromatic Compounds

* Reactive Vapors in the Nasal Cavity

* Alkanes, Oxyhydrocarbons, and Related Compounds

* Pesticides and Persistent Organic Pollutants

* Dioxin and Related Compounds

* Metals and Inorganic Compounds

* Drugs

* Antineoplastic Agents

* Perinatal Transfer

* Mixtures

* Dermal Exposure Models

In addition to pinpointing specific information, readers can explore diverse modeling techniques and applications. An authoritative reference for toxicologists, ecotoxicologists, risk assessors, regulators, pharmacologists, pharmacists, and graduate students in pharmacokinetics and toxicology, Physiologically-Based Pharmacokinetic Modeling compiles information from leaders in the field and discusses future directions for PBPK modeling.

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