埃里克·坎德尔(Eric R.Kandel)1929年出生于奥地利的维也纳,1956年毕业于美国纽约大学,获医学博士学位。1983年至今任哥伦比亚大学生物化学与分子生物物理学系教授、霍华休斯医学研究中心高级研究员。2000年获诺贝尔生理学或医学奖。
From Publishers Weekly
When, as a medical student in the 1950s, Kandel said he wanted to locate the ego and id in the brain, his mentor told him he was overreaching, that the brain had to be studied "cell by cell." After his initial dismay, Kandel took on the challenge and in 2000 was awarded a Nobel Prize for his groundbreaking research showing how memory is encoded in the brain's neuronal circuits. Kandel's journey into the brain spans five decades, beginning in the era of early research into the role of electrical currents flowing through neurons and ending in the age of genetic engineering. It took him from early studies of reflexes in the lowly squid to the founding of a bioengineering firm whose work could some day develop treatments for Alzheimer's and on to a rudimentary understanding of the cellular mechanisms underlying mental illness. Kandel's life also took him on another journey: from Vienna, which his Jewish family fled after the Anschluss, to New York City and, decades later, on visits back to Vienna, where he boldly confronted Austria's unwillingness to look at its collusion in the Final Solution. For anyone considering a career in science, the early part of this intellectual autobiography presents a fascinating portrait of a scientist's formation: learning to trust his instincts on what research to pursue and how to pose a researchable question and formulate an experiment. Much of the science discussion is too dense for the average reader. But for anyone interested in the relationship between the mind and the brain, this is an important account of a creative and highly fruitful career. 50 b&w illus. (Mar.)
Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved. --This text refers to the Hardcover edition.
From Scientific American
Kandel, who received the Nobel Prize in 2000, traces advances in understanding learning and memory. His own groundbreaking findings showed that learning produces changes in behavior by modifying the strength of connections between nerve cells. He conveys his immense grasp of the science beautifully, but it is his personal recollections that make the book especially compelling. He begins with his searing childhood memories of the German annexation of Austria and his family’s escape to the U.S. when he was nine. And he ends with a conference he organized in Vienna to examine the strange reluctance of Austria (unlike Germany) to acknowledge its role in the Holocaust. One comes away in awe of the scientific advances—and of a life well and fully lived.
Editors of Scientific American --This text refers to the Hardcover edition.
从来没有一本科普书让我感觉到这么肌无力,虽然连续攻读了几天,做了十几页笔记,依然觉得这本书信息量太大,思考过于深邃,难以一时消化。我仅有的薄弱的高中生物学知识常常在一些稍微专业的生物学概念和术语上很迷惘,而我的专业知识却集中在制造业和IT之上,因此只能大...
评分这是我读过的最好的科普著作,等慢慢消化了再写个书评吧,先把几个勘误贴一下(整本书的翻译仍然是非常高质量的)。 P197倒数第二段。 译文:Watkins和Graham Collingridge发现在海马中谷氨酸充当两种受体:AMPA受体和NMDA受体,AMPA受体调节一般的突触传递并且在突触前神经元...
评分这是一本不可多得的好书,五星推荐。 书名“in search of memory”一语双关,一方面指作者的研究领域,一方面又指本书的内容:凭借记忆写出的人生自传。 说起脑科学,在数年前差点和它结下缘分。当时在研究生入学选择时有几个可能的去处,其中之一是中科院脑认知科学研究所(似...
评分从来没有一本科普书让我感觉到这么肌无力,虽然连续攻读了几天,做了十几页笔记,依然觉得这本书信息量太大,思考过于深邃,难以一时消化。我仅有的薄弱的高中生物学知识常常在一些稍微专业的生物学概念和术语上很迷惘,而我的专业知识却集中在制造业和IT之上,因此只能大...
评分这是一本不可多得的好书,五星推荐。 书名“in search of memory”一语双关,一方面指作者的研究领域,一方面又指本书的内容:凭借记忆写出的人生自传。 说起脑科学,在数年前差点和它结下缘分。当时在研究生入学选择时有几个可能的去处,其中之一是中科院脑认知科学研究所(似...
此书将我领入神经科学的世界。他是学术大牛,也是很好的presenter。
评分这书应该叫《科学家的自我修养》。同时也是神经科学很好的入门书(前提是你要有一些生物化学方面的知识)。
评分其中内容大部分从其它渠道比如科学美国人了解了。所以所获不多。
评分好看!
评分信息量超大……需要消化……坚持reductionist原则,力排众议地选取细胞大且神经环路简单的海兔(Aplysia)作为研究对象,发现短时记忆和长时记忆的细胞机制。站在学科交叉处,善于吸收来自不同学科的观点和技术,积极参与跨学科和技术背景的合作,乐于尝新。用不同的理论视角,重新审视重新叙述自己的研究问题,因而走的深和远。
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