1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Stefan Grimm
Part I Viral Anticancer Genes
2 Signalling of Apoptin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
Jessica Bullenkamp and Mahvash Tavassoli
3 Apoptin Towards Safe and Efficient Anticancer Therapies . . . . . . . 39
Claude Backendorf and Mathieu H.M. Noteborn
4 Induction of Cancer-Specific Cell Death by the Adenovirus
E4orf4 Protein . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61
Tamar Kleinberger
5 Tumor Suppressing Properties of Rodent Parvovirus NS1
Proteins and Their Derivatives . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
Ju¨rg P.F. Nu¨esch and Jean Rommelaere
Part II Cellular Anticancer Genes
6 MDA-7/IL-24: Multifunctional Cancer Killing Cytokine . . . . . . . . 127
Mitchell E. Menezes, Shilpa Bhatia, Praveen Bhoopathi,
Swadesh K. Das, Luni Emdad, Santanu Dasgupta, Paul Dent,
Xiang-Yang Wang, Devanand Sarkar, and Paul B. Fisher
7 Cancer-Selective Apoptosis by Tumor Suppressor Par-4 . . . . . . . . 155
Nikhil Hebbar, Tripti Shrestha-Bhattarai, and Vivek M. Rangnekar
8 Tumor-Necrosis-Factor-Related Apoptosis-Inducing
Ligand (TRAIL) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 167
Simone Fulda
vii
9 SIRT6: A Promising Target for Cancer Prevention
and Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 181
Michael Van Meter, Vera Gorbunova, and Andrei Seluanov
10 An Overview of Brevinin Superfamily: Structure, Function
and Clinical Perspectives . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 197
Anna Savelyeva, Saeid Ghavami, Padideh Davoodpour,
Ahmad Asoodeh, and Marek J. Łos
11 Isolation and Characterization of the Anticancer Gene Organic
Cation Transporter Like-3 (ORCTL3) . . . . . . . . . . . . . . . . . . . . . . 213
Ghada AbuAli and Stefan Grimm
Part III Anticancer Gene Therapy
12 Introduction of Genes via Sonoporation and Electroporation . . . . . 231
Christina Kalli, Wey Chyi Teoh, and Edward Leen
13 Anticancer Gene Transfer for Cancer Gene Therapy . . . . . . . . . . . 255
Evangelos Pazarentzos and Nicholas D. Mazarakis
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 281
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