Walter Isaacson, a professor of history at Tulane, has been CEO of the Aspen Institute, chair of CNN, and editor of Time. He is the author of Leonardo da Vinci; The Innovators; Steve Jobs; Einstein: His Life and Universe; Benjamin Franklin: An American Life; and Kissinger: A Biography, and the coauthor of The Wise Men: Six Friends and the World They Made. Visit him at Isaacson.Tulane.edu.
The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.
Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.
The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.
Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?
After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.
I enjoyed reading the book. I appreciate that Walter has explained the concepts of biochemistry, a subject rather unfamiliar to me, in a both thorough and understandable way, covering a wide range of topics around CRISPR, including the history, the scientif...
評分I enjoyed reading the book. I appreciate that Walter has explained the concepts of biochemistry, a subject rather unfamiliar to me, in a both thorough and understandable way, covering a wide range of topics around CRISPR, including the history, the scientif...
評分 評分这本书主要围绕Jennifer Doudna, 回顾了CRISPR和基因编辑的探讨. 写的跌宕起伏, 描述了科学研究者之间秘密竞争同时又对自然保护好奇心展开合作. 不同的研究者展示了非常不一样的个性. 后面几章讨论bioethics 和人类基因改造, 我不大喜欢. 作者自己个人想法太多,觉得有点肤浅, ...
評分挺好看的,實效性很強,跟covid聯係很緊密。最喜歡看這種眾人拾柴火焰高,每個人的研究都為某個成功的發現奠定基石的故事。所以其實叫code breakers確實更閤適,很喜歡Doudna和Charpentier這種微妙的情感,既是閤作者又有點小競爭的感覺。中間有段講gene editing的好處和壞處覺得有點離題,好在後麵又拉迴來瞭
评分很精彩的故事,高尖端的科技,科學傢的爭名奪利,關於道德的爭論,都很有意思,不過感覺作者夾帶私貨略多
评分很精彩的故事,高尖端的科技,科學傢的爭名奪利,關於道德的爭論,都很有意思,不過感覺作者夾帶私貨略多
评分should be the code breakers. 一開始是抱著Bill Gates 推薦過所以想看,不得不說有點失望。但是看到Bill and Melinda Gates Foundation 資助瞭以後就也沒那麼意外瞭。
评分偵探小說一樣,好看的簡直停不下來,比前一步著作 達芬奇 好看的多,讀達芬奇的時候 一直瞌睡。這本書簡直停不下來。微積分的發現,大傢爭來爭去,DNA結構的發現,大傢爭來爭去,人類基因組計劃,大傢爭來爭去, crisper-cas9,大傢爭來爭去。其實你發現沒有,個人的貢獻是有限的,沒有誰,地球照樣轉。科學的發現和進步,是一個水到渠成,成韆上萬的人一步一步做齣來的,個人的貢獻往往被放大,而更多的人則被忽略。感覺Jennifer是一個很愛搶功勞的人,也許是中國人都zhangfeng有同情。不過她的閤作者都疏遠瞭她。雞血的中國媽媽可以看看,美國也有尖子班,張峰也上補習班的,不過他上的是將熒光蛋白重組錶達的相關工作。最不喜歡書裏麵的thought experiment, 是這本書最大的敗筆
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